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Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation.
Tang X, Tu G, Yang G, Wang X, Kang L, Yang L, Zeng H, Wan X, Qiao Y, Cui X, Liu M, Hou Y. Tang X, et al. Cancer Lett. 2019 Jun 28;452:79-89. doi: 10.1016/j.canlet.2019.02.044. Epub 2019 Mar 6. Cancer Lett. 2019. PMID: 30851420 Free PMC article.
Destruction of the autocrine TGF-beta1/miR-200s/miR-221/DNMT3B signaling led to demethylation of miR-200s promoters and further restored the NF phenotypes. Moreover, we confirmed that TCF12, the target of miR-141, stimulated c-Myc/Cyclin D1 axis in breast cancer cells to p …
Destruction of the autocrine TGF-beta1/miR-200s/miR-221/DNMT3B signaling led to demethylation of miR-200s promoters and further restored the …
Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling.
Tang X, Hou Y, Yang G, Wang X, Tang S, Du YE, Yang L, Yu T, Zhang H, Zhou M, Wen S, Xu L, Liu M. Tang X, et al. Cell Death Differ. 2016 Jan;23(1):132-45. doi: 10.1038/cdd.2015.78. Epub 2015 Jun 12. Cell Death Differ. 2016. PMID: 26068592 Free PMC article.
CAF activation may be governed by the targets of miR-200 s, Fli-1 and TCF12, which are responsible for cell development and differentiation; Fli-1 and TCF12 were obviously elevated in CAFs. ...The upregulation of fibronectin and lysyl oxidase directly by miR-200 or …
CAF activation may be governed by the targets of miR-200 s, Fli-1 and TCF12, which are responsible for cell development and different …
Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas.
Droog M, Nevedomskaya E, Kim Y, Severson T, Flach KD, Opdam M, Schuurman K, Gradowska P, Hauptmann M, Dackus G, Hollema H, Mourits M, Nederlof P, van Boven H, Linn SC, Wessels L, van Leeuwen FE, Zwart W. Droog M, et al. Cancer Res. 2016 Jul 1;76(13):3773-84. doi: 10.1158/0008-5472.CAN-14-1813. Epub 2016 May 6. Cancer Res. 2016. PMID: 27197147
Multifactorial ChIP-seq data integration from the endometrial cancer cell line Ishikawa illustrated a functional genomic network involving ERalpha and FOXA1 together with the enhancer-enriched transcriptional regulators p300, FOXM1, TEAD4, FNFIC, CEBP8, and TCF12. Immunohi …
Multifactorial ChIP-seq data integration from the endometrial cancer cell line Ishikawa illustrated a functional genomic network involving E …